Latest News and Updates

FDA approves Awiqli the first once‑weekly basal insulin for type 2 diabetes

News & Updates

FDA Approves First in Class FcRn Blocker IMAAVY (Nipocalimab aahu) for Warm Autoimmune Hemolytic Anemia

On August 24, 2026, the U.S. Food and Drug Administration approved Janssen Biotech’s IMAAVY (nipocalimab-aahu) injection for adult and pediatric patients aged 12 years and older currently or previously treated with corticosteroids (1,2). This landmark decision represents the first therapy proven safe and effective specifically for warm autoimmune hemolytic anaemia (wAIHA). As a first-in-class treatment, IMAAVY offers clinical management for an underserved community that has h

Dr. Manisha Dadlani

1 day ago

Daraxonrasib: Restoring Hope in Pancreatic Cancer Management

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most difficult challenges in modern oncology. It is a condition characterised by aggressive tumour growth and a high mortality rate, with a five-year survival rate that persists below 13% (1). Because the disease is often asymptomatic in its early stages, the majority of patients are diagnosed only after the cancer has become metastatic and unresectable. While this mutation drives the disease, the RAS protein was long

Dr. Manisha Dadlani

Aug 31

Upcoming Medical Congresses

ILAE - Epilepsy Congress 2026 Date of event: September 5-9, 2026 Location: Athens, Greece The conference brings together the global cardiology community to explore breakthrough research, gain practical clinical insights, and connect with leading experts from around the world. Through keynote sessions, interactive discussions, and hands-on learning experiences, participants will discover the latest scientific advancements designed to enhance clinical practice and improve pati

Ms. Vidya Kalyani

Aug 18

Clinical Trials & Drug Cards

Ustekinumab (STELARA®)

Drug class: CDK4/6 inhibitor Mechanism of Action Interleukin 12 (IL 12) and interleukin 23 (IL 23) are key drivers of chronic inflammation. Ustekinumab, a fully human immunoglobulin G1 (IgG1) monoclonal antibody, targets the p40 subunit shared by IL 12 and IL 23 heterodimers. By blocking this subunit, ustekinumab prevents IL 12/IL 23 binding to the IL 12 receptor β1 (IL 12Rβ1) on immune cell surfaces. This inhibition disrupts downstream differentiation and activation of T hel

Dr. Jaimee George

2 hours ago

Ribociclib (Kisqali)

Drug class: CDK4/6 inhibitor Mechanism of Action Ribociclib is an orally administered, highly selective small molecule inhibitor of cyclin dependent kinases 4 and 6 (CDK4/6). It is approved in combination with other agents for the treatment of HR positive, HER2 negative advanced or metastatic breast cancer (1). Inside cells, CDK4/6 act as “ignition switches” for cell division. When bound to Cyclin D, they activate signaling that drives the cell cycle forward. In HR positive b

Ms. Mohana Ragavi

5 days ago

Liraglutide (Victoza®)

Drug class: GLP-1 RA Mechanism of Action Liraglutide is a human GLP-1 analogue that activates GLP-1 receptors, enhancing glucose-dependent insulin secretion, suppressing glucagon secretion, slowing gastric emptying, and reducing appetite. This results in improved glycemic control (1). Approved Indications Type 2 diabetes mellitus (1) Cardiovascular risk reduction (1) Dosage and Administration Initial: 0.6 mg SC once daily for 1 week. Increase to 1.2 mg once daily, up to 1.8 m

Ramesh Mylapilli

6 days ago

Spotlight

Clinical Spotlight: Flonase Nasal Spray for Rhinitis Management

Chronic inflammatory diseases of the nasal mucosa such as allergic rhinitis, rhinosinusitis, and nasal polyposis pose a significant clinical burden but can be effectively managed with topically active corticosteroids (1,2). Allergic rhinitis is a chronic inflammatory disorder of the nasal mucosa triggered by environmental allergens (1). Allergic rhinitis is highly prevalent in India, with recent large‑scale studies showing that more than half of patients presenting with nasal

Dr. Manisha Dadlani

Sep 1

Prenatal care spotlight: The double marker test.

1. Overview The double marker test is a crucial prenatal assessment tool used during the first trimester of pregnancy. Its main purpose is to detect pregnancies that are at elevated risk for the onset of chromosomal disorders. The test integrates maternal age with particular biochemical indicators to evaluate fetal well-being (1). The double marker test, also known as the double test, measures two serum markers: free beta-human chorionic gonadotropin (free beta-hCG) and pregn

Dr. Manisha Dadlani

Apr 21

Inclisiran - A game changer in ASCVD management

Atherosclerotic cardiovascular disease (ASCVD) is amongst the leading causes of death worldwide, accounting for an estimated 19 million deaths each year (1). The mortality rates are even higher in India linked with an earlier age of onset and greater severity of the disease (2,3). More than half of cardiac deaths in India occur below the age of 50 years and 25% occur below the age of 40 years. The skyrocketing rates are due to a combination of risk factors which include dysli

Dr. Geetika Gupta

Sep 10, 2025

Patient Stories & Patient Education Literature

Urinary Incontinence Explained: Symptoms, Causes and Care

Sanjay, a 47‑year‑old IT professional, led a sedentary lifestyle with long working hours and little physical activity. Over the past few months, he began experiencing unexpected urine leakage, especially when laughing loudly or sneezing. With no prior health issues, these episodes left him confused and frustrated. After repeated incidents, he finally consulted his physician. Rekha, a 30‑year‑old mother of a two‑year‑old, faced similar challenges. Along with leakage, she frequ

Dr. Kaveri Purandhar

Aug 27

Beyond The Baby Blues: A Journey Through Postpartum Depression

Motherhood is often described as a joyful and transformative journey, but for some women, the postpartum period can also be overwhelming. Sandhya, a 28-year-old first-time mother, had expected happiness along with the responsibilities of caring for a newborn. Instead, her experience after delivery did not match those expectations. Each day brought new struggles. She noticed persistent changes in her mood, emotions, and energy levels, but could not understand what was happenin

Dr. Kaveri Purandhar

Aug 22

Healthy Arteries, Healthy Life: A Guide to Atherosclerosis.

Have you ever thought about how what you eat today can affect your heart tomorrow? Let’s talk about cholesterol and a condition called atherosclerosis (1,2). Atherosclerosis is when your arteries gradually become blocked over time. The tricky part? You may not notice symptoms until it becomes serious (3). What is Cholesterol? Cholesterol is a fat-like substance your body needs to build cells, make hormones, and produce Vitamin D. Your liver makes most of it, but foods like

Ms. Mohana Ragavi

Aug 18

Case Reports

Acute decompensated heart failure in a 56-year old female patient with hypertension, type-2 diabetes, and hyperlipidemia: A clinical case report.

Abstract This is a case of a 56-year-old woman who has had high blood pressure for 8 years, type 2 diabetes for 6 years, and high cholesterol. She started experiencing worse symptoms, including trouble breathing when active and even when resting, difficulty breathing while lying down, sudden nighttime breathing problems, a dry cough, tiredness, a 3 kg weight gain, and mild chest pain. The initial evaluation of the cardiovascular examination revealed JVD (jugular vein distensi

Ms. Pallavi Mukku

Mar 14

Managing Enteric Fever in a 24-year old patient

A 24-year-old female presented to the outpatient clinic with a two-week history of high-grade fever accompanied by generalized myalgia, fatigue, severe frontal headache, and watery, non-bloody diarrhea occurring three to five times daily. She also reported poor appetite, progressive weakness, and noticed brownish pigmentation in urine over the preceding few days. The symptoms had initially begun with abdominal pain and headache before progressively worsening. The patient had

Ms. Hima Saxena

Sep 8, 2025

Guidelines

Nutritional priorities to support GLP-1 therapy

Glucagon-like peptide-1 (GLP-1) agonists are a class of medication utilized to treat obesity and type 2 diabetes. Some examples include Exenatide, Liraglutide, Dulaglutide, and Semaglutide. GLP-1 agonists act by lowering serum glucose levels and thereby manage metabolism in affected patients (1). Glucagon-like peptide-1 (GLP-1) agonists are rapidly becoming central to evidence-based treatment of obesity. These agents not only offer substantial and sustained weight loss but a

Ms. Hima Saxena

Sep 8, 2025

A comprehensive physician's guide to vitamin B12 by PAN India Group.

Vitamin B12 deficiency is believed to be endemic in Indian population. Our diet is largely vegetarian which is considered to be one of the key factor for the deficiency. People with diabetes are particularly prone to Vitamin B12 deficiency (1). There is an urgent need for evidence-based guidelines that can help healthcare professionals with the management of B12 deficiency. Physician's Guide to Vitamin B12 by PAN India Physicians Association for Nutrition India (PAN India) d

Ramesh Mylapilli

Sep 8, 2025