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US FDA approves Lenacapavir (Yeztugo®) for HIV prevention

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World Cardiology Conference - 2026 Date of event: August 28-31, 2026 Location: Munich, Germany The conference offers a premier global forum to explore the latest advancements in cardiology and shape the future of cardiovascular care. This year's comprehensive scientific program features a special Spotlight on Artificial Intelligence, highlighting the transformative role of AI in diagnosis, clinical decision-making, and patient management through hands-on workshops, live demon

Ms. Vidya Kalyani

6 days ago

FDA approves Roctavian gene therapy for severe Haemophilia A

Halfway through the year 2023, BioMarin bagged the approval for an “adeno-associated virus serotype 5 (AAV5)” gene therapy by the United States Food and Drug Administration (FDA). The therapy is for adults with a life-threatening and rare genetic condition known as Haemophilia A. In this article we will discuss about the novel therapy and the studies leading to its approval. Haemophilia A, also referred to as an X-linked disorder affects 1 in 5,000 male births. The sex-linke

Ms. Pragya Agarwal

Sep 10, 2025

U.S. FDA approves low dose Colchicine for ASCVD risk reduction

Atherosclerotic cardiovascular disease (ASCVD) is a leading cause of morbidity and mortality worldwide, affecting over 500 million individuals globally and resulting in approximately 19 million deaths annually. It is caused by the build-up of plaque that leads to hardening of the arteries. It can limit blood flow through the arteries which can result in severe conditions such as coronary heart disease, stroke, angina, or peripheral artery disease. The control of traditional c

Dr. Uttara Shankar

Sep 10, 2025

Clinical Trials

Oral Semaglutide vs. Sitagliptin: PIONEER 3 Study

Rosenstock J et al. conducted the PIONEER 3 trial to compare the effectiveness of oral Semaglutide against Sitagliptin in adult Type 2 diabetes patients who were not adequately controlled on Metformin alone or with sulfonylurea. This study robustly evaluated the impacts on HbA1c reduction and the changes in body weight from baseline (1). Study Summary About the Author Ms. Silpa Rani Gajavalli is a postgraduate in pharmaceutical science (M Pharmacy). She has a wealth of academ

Ms. Silpa Rani Gajavalli

Apr 20

Oral Semaglutide vs Empagliflozin: PIONEER 2 Study

Type 2 diabetes mellitus (T2DM) is a major global health challenge, disproportionately affecting low- and middle-income countries. In 2024, 589 million adults aged 20–79 years were living with diabetes, causing 3.4 million deaths and over US$1 trillion in health expenditure; prevalence is projected to reach 853 million by 2050 (1). Beyond hyperglycaemia, T2D is increasingly recognized as a complex, multisystem disorder associated with the cardiovascular, renal, and hepatic sy

Ms. Tanvi Goel

Apr 6

Bevacizumab treatment for patients with recurrent ovarian cancer

Ovarian cancer is highly prevalent and accounts for high mortality rate among cancers relating to female reproductive system (1). As per the Global Cancer Statistics (2020), every year almost 24,000 women are diagnosed with ovarian cancer. Most of the patients are diagnosed at advanced stages. Unfortunately, it is noted that 70% of patients treated with standard Platinum chemotherapy have recurrence of ovarian cancer within 18 to 28 months (1, 2). Challenges with recurrent ov

Dr. Sishir Kumar

Sep 9, 2025

Spotlight

Prenatal care spotlight: The double marker test.

1. Overview The double marker test is a crucial prenatal assessment tool used during the first trimester of pregnancy. Its main purpose is to detect pregnancies that are at elevated risk for the onset of chromosomal disorders. The test integrates maternal age with particular biochemical indicators to evaluate fetal well-being (1). The double marker test, also known as the double test, measures two serum markers: free beta-human chorionic gonadotropin (free beta-hCG) and pregn

Dr. Manisha Dadlani

Apr 21

Inclisiran - A game changer in ASCVD management

Atherosclerotic cardiovascular disease (ASCVD) is amongst the leading causes of death worldwide, accounting for an estimated 19 million deaths each year (1). The mortality rates are even higher in India linked with an earlier age of onset and greater severity of the disease (2,3). More than half of cardiac deaths in India occur below the age of 50 years and 25% occur below the age of 40 years. The skyrocketing rates are due to a combination of risk factors which include dysli

Dr. Geetika Gupta

Sep 10, 2025

Semaglutide – the first type 2 diabetes oral pill in its class

Diabetes is a global epidemic affecting around 463 million adults worldwide (1). India is considered the diabetes capital of the world. Around 69.9 million patients are expected to be suffering from Type 2 diabetes by 2025. This is projected to increase to 80 million by 2023 which is a 266% increase (2). Current treatment guidelines recommend lifestyle changes, such as diet and exercise along with pharmacotherapy. Metformin is considered as gold standard and is routinely pres

Dr. Lokesh Naik

Sep 10, 2025

Patient Stories & Patient Education Literature

Beyond The Baby Blues: A Journey Through Postpartum Depression

Motherhood is often described as a joyful and transformative journey, but for some women, the postpartum period can also be overwhelming. Sandhya, a 28-year-old first-time mother, had expected happiness along with the responsibilities of caring for a newborn. Instead, her experience after delivery did not match those expectations. Each day brought new struggles. She noticed persistent changes in her mood, emotions, and energy levels, but could not understand what was happenin

Dr. Kaveri Purandhar

2 days ago

Healthy Arteries, Healthy Life: A Guide to Atherosclerosis.

Have you ever thought about how what you eat today can affect your heart tomorrow? Let’s talk about cholesterol and a condition called atherosclerosis (1,2). Atherosclerosis is when your arteries gradually become blocked over time. The tricky part? You may not notice symptoms until it becomes serious (3). What is Cholesterol? Cholesterol is a fat-like substance your body needs to build cells, make hormones, and produce Vitamin D. Your liver makes most of it, but foods like

Ms. Mohana Ragavi

6 days ago

Mucus in stool: What it means and how to manage it.

Noticing mucus in stool can feel worrying, but small amounts of clear or white mucus are completely normal (1,2). Mucus is a natural substance made by your intestines. It helps stool move smoothly and protects your gut (2). Mucus in stool can occur across all age groups, including adults, children, and infants (1,3). Excessive mucus, or mucus accompanied by blood and abdominal pain, may point to an underlying digestive issue (2). This article will speak about what triggers mu

Dr. Naziya Begum

Apr 28

Case Reports

Acute decompensated heart failure in a 56-year old female patient with hypertension, type-2 diabetes, and hyperlipidemia: A clinical case report.

Abstract This is a case of a 56-year-old woman who has had high blood pressure for 8 years, type 2 diabetes for 6 years, and high cholesterol. She started experiencing worse symptoms, including trouble breathing when active and even when resting, difficulty breathing while lying down, sudden nighttime breathing problems, a dry cough, tiredness, a 3 kg weight gain, and mild chest pain. The initial evaluation of the cardiovascular examination revealed JVD (jugular vein distensi

Ms. Pallavi Mukku

Mar 14

Managing Enteric Fever in a 24-year old patient

A 24-year-old female presented to the outpatient clinic with a two-week history of high-grade fever accompanied by generalized myalgia, fatigue, severe frontal headache, and watery, non-bloody diarrhea occurring three to five times daily. She also reported poor appetite, progressive weakness, and noticed brownish pigmentation in urine over the preceding few days. The symptoms had initially begun with abdominal pain and headache before progressively worsening. The patient had

Ms. Hima Saxena

Sep 8, 2025

Guidelines

Nutritional priorities to support GLP-1 therapy

Glucagon-like peptide-1 (GLP-1) agonists are a class of medication utilized to treat obesity and type 2 diabetes. Some examples include Exenatide, Liraglutide, Dulaglutide, and Semaglutide. GLP-1 agonists act by lowering serum glucose levels and thereby manage metabolism in affected patients (1). Glucagon-like peptide-1 (GLP-1) agonists are rapidly becoming central to evidence-based treatment of obesity. These agents not only offer substantial and sustained weight loss but a

Ms. Hima Saxena

Sep 8, 2025

A comprehensive physician's guide to vitamin B12 by PAN India Group.

Vitamin B12 deficiency is believed to be endemic in Indian population. Our diet is largely vegetarian which is considered to be one of the key factor for the deficiency. People with diabetes are particularly prone to Vitamin B12 deficiency (1). There is an urgent need for evidence-based guidelines that can help healthcare professionals with the management of B12 deficiency. Physician's Guide to Vitamin B12 by PAN India Physicians Association for Nutrition India (PAN India) d

Ramesh Mylapilli

Sep 8, 2025