Drug class: Hormone (recombinant human insulin or insulin analog) Mechanism of Action Insulin glargine (IGlr), a recombinant human insulin analog (21A-Gly-30Ba-L-Arg-30Bb-L-Arg-; HOE 901), helps regulate glucose metabolism. It binds to insulin receptors, a tyrosine kinase receptor, triggering a conformational change in the intracellular beta catalytic domains. This induces autophosphorylation and recruits docking proteins, including phosphatidylinositol-4,5-bisphosphate 3-kin