top of page
Ustekinumab (STELARA®)
Drug class: CDK4/6 inhibitor Mechanism of Action Interleukin 12 (IL 12) and interleukin 23 (IL 23) are key drivers of chronic inflammation. Ustekinumab, a fully human immunoglobulin G1 (IgG1) monoclonal antibody, targets the p40 subunit shared by IL 12 and IL 23 heterodimers. By blocking this subunit, ustekinumab prevents IL 12/IL 23 binding to the IL 12 receptor β1 (IL 12Rβ1) on immune cell surfaces. This inhibition disrupts downstream differentiation and activation of T hel
Dr. Jaimee George
2 hours ago6 min read
bottom of page