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Pertuzumab (Perjeta®)
Drug class: HER2-directed monoclonal antibody Mechanism of Action Pertuzumab is a recombinant humanized monoclonal antibody that binds to the dimerization subdomain II of the human epidermal growth factor receptor 2 (HER2). It inhibits HER2 from forming heterodimers with other HER family receptors, particularly HER3, thereby blocking ligand-dependent signaling pathways involved in tumor cell proliferation and survival. Pertuzumab also mediates antibody-dependent cellular cyto
Ramesh Mylapilli
6 hours ago4 min read
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