Cardiovascular outcomes with Semaglutide in high-risk patients
Updated: Sep 8
Oral Semaglutide was approved by the FDA in September 2019 to improve blood glucose control in adult patients with type 2 diabetes (1).
Semaglutide is a GLP-1 receptor agonist that stimulates the β-cells in the pancreas for insulin secretion, suppresses glucagon secretion from pancreatic α-cells, and delays gastric emptying. It is the first GLP-1 receptor agonist formulated for oral administration. An absorption enhancement known as sodium N-(8-[2-hydroxylbenzoyl] amino) caprylate (SNAC) is used as a co-formulation that promotes its absorption in the stomach and increases the pH in the stomach which protects the peptide from enzymatic degradation (1).
Clinical Evidence - SOUL study
McGuire DK et al, assessed cardiovascular outcomes with Oral Semaglutide in patients with type 2 diabetes, atherosclerotic cardiovascular disease, chronic kidney disease, or both. The primary efficacy outcome of the SOUL study was major adverse cardiovascular outcomes assessed in a time-to-first-event analysis (2).
Study Summary
About the Author
Ms. Roma Joglekar is a Sports Physiotherapist with three years of on-field experience in helping athletes recover, improve and excel in their performance. Roma is passionate about medical science and has keen interest in simplifying complex medical information and share it with healthcare professionals, patients, care givers and the general population.
Abbreviations
HbA1c: Glycated haemoglobin; MACE: Major Adverse Cardiovascular Events.
References
Hughes S, Neumiller JJ. Oral Semaglutide. Clin Diabetes. 2020;38(1):109-111.
McGuire DK, Marx N, Mulvagh SL, et al; SOUL Study Group. Oral Semaglutide and Cardiovascular Outcomes in High-Risk Type 2 Diabetes. N Engl J Med. 2025 May 29;392(20):2001-2012.
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